Abstract | BACKGROUND:
PIM kinases are mediators of cytokine signalling pathways in hematopoietic cells and contribute to the progression of certain types of leukemia and solid tumor. Here the prognostic impact of proto-oncogene PIM-1 was analyzed in gastric carcinoma. PATIENTS AND METHODS:
Cancer tissues of 117 patients with potentially curative (R0) resections for gastric cancer were immunohistochemically stained for PIM-1. RESULTS: Cytoplasmic immunoreactivity for PIM-1 in tumor (46%) was higher (p=0.003) compared to that in gastric glands (16%) and foveolae (1%). PIM-1 immunoreactivity in gastric carcinoma correlated with tumor grading (p<0.05) and Laurén category (p<0.02). Overexpression of PIM-1 in gastric glands (p<0.001) was associated with formation of lymph node metastases (p=0.035) and survival (p=0.04). Multivariate analysis of PIM-1 expression in gastric glands confirmed its association with prognosis. CONCLUSION:
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Authors | Ute Warnecke-Eberz, Elfriede Bollschweiler, Uta Drebber, Ralf Metzger, Stephan E Baldus, Arnulf H Hölscher, Stefan Mönig |
Journal | Anticancer research
(Anticancer Res)
Vol. 29
Issue 11
Pg. 4451-5
(Nov 2009)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 20032391
(Publication Type: Journal Article)
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Chemical References |
- MAS1 protein, human
- Proto-Oncogene Mas
- PIM1 protein, human
- Proto-Oncogene Proteins c-pim-1
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Prognosis
- Proto-Oncogene Mas
- Proto-Oncogene Proteins c-pim-1
(biosynthesis, metabolism)
- Stomach Neoplasms
(enzymology, pathology)
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