Abstract | BACKGROUND: OBJECTIVES: METHODS: Thirty-two individuals with asthma and measurable airway responsiveness to adenosine monophosphate ( AMP) were randomized and double blinded to cutaneous administration of either ten Necator americanus larvae, or histamine solution (placebo), and followed for 16 weeks. The primary outcome was the change in provocation dose of inhaled AMP required to reduce forced expiratory volume in 1 s by 20% (PD(20) AMP) from baseline to week 16. Secondary outcomes included change in several measures of asthma control and allergen skin sensitivity and the occurrence of adverse effects. RESULTS: Mean PD(20) AMP improved in both groups, more in the hookworm [1.49 doubling doses (DD)] than the placebo group (0.98 DD), but the difference between groups was not significant (0.51 DD; 95% confidence interval: -1.79 to 2.80; P=0.65). There were no significant differences between the two groups for other measures of asthma control or allergen skin sensitization. Infection was generally well tolerated. CONCLUSIONS: Experimental infection with ten hookworm larvae in asthma did not result in significant improvement in bronchial responsiveness or other measures of asthma control in this study. However, infection was well tolerated and resulted in a non-significant improvement in airway responsiveness, indicating that further studies that mimic more closely natural infection are feasible and should be undertaken.
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Authors | J R Feary, A J Venn, K Mortimer, A P Brown, D Hooi, F H Falcone, D I Pritchard, J R Britton |
Journal | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
(Clin Exp Allergy)
Vol. 40
Issue 2
Pg. 299-306
(Feb 2010)
ISSN: 1365-2222 [Electronic] England |
PMID | 20030661
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Placebos
- Adenosine Monophosphate
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Topics |
- Adenosine Monophosphate
(administration & dosage, adverse effects)
- Administration, Inhalation
- Adult
- Animals
- Asthma
(complications, immunology, prevention & control, therapy)
- Bronchial Provocation Tests
- Double-Blind Method
- Female
- Forced Expiratory Volume
- Humans
- Larva
(immunology, physiology)
- Male
- Necator americanus
(growth & development, immunology, physiology)
- Necatoriasis
(complications, diagnosis, parasitology)
- Placebos
- Safety
- Skin Tests
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