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High poly(adenosine diphosphate-ribose) polymerase expression and poor survival in advanced-stage serous ovarian cancer.

AbstractOBJECTIVE:
To estimate the range of poly(adenosine diphosphate [ADP]-ribose) polymerase expression in serous ovarian cancers and to determine whether expression is associated with response to therapy and outcome.
METHODS:
Immunostaining for poly(ADP-ribose) polymerase was performed in 186 paraffin-embedded, serous ovarian cancers. Nuclear poly(ADP-ribose) polymerase expression was quantified using a scoring system that assesses both staining intensity and percentage of cells staining. Kaplan-Meier analysis was performed to evaluate the relationship between poly(ADP-ribose) polymerase expression and overall survival.
RESULTS:
High poly(ADP-ribose) polymerase expression was present in 54% of serous cancers but was not associated with stage or grade. There was no difference in the rate of complete clinical response to primary chemotherapy between cases with low poly(ADP-ribose) polymerase expression (70%) compared with those with high poly(ADP-ribose) polymerase expression (71%). However, high poly(ADP-ribose) polymerase expression was associated with significantly worse median overall survival (36 compared with 43 months, P=.04, hazard ratio 0.71).
CONCLUSION:
Expression of poly(ADP-ribose) polymerase in ovarian cancers is heterogeneous, and high expression in serous ovarian cancers is associated with worse overall survival. These data suggest that evaluation of poly(ADP-ribose) polymerase expression in the primary cancer could potentially allow selective use of poly(ADP-ribose) polymerase inhibitors in patients most likely to respond.
LEVEL OF EVIDENCE:
III.
AuthorsJason C Barnett, Sarah M Bean, John M Nakayama, Eiji Kondoh, Susan K Murphy, Andrew Berchuck
JournalObstetrics and gynecology (Obstet Gynecol) Vol. 115 Issue 1 Pg. 49-54 (Jan 2010) ISSN: 1873-233X [Electronic] United States
PMID20027033 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Poly(ADP-ribose) Polymerases
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Middle Aged
  • Ovarian Neoplasms (enzymology, mortality, pathology, surgery)
  • Poly(ADP-ribose) Polymerases (metabolism)
  • Prognosis
  • Young Adult

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