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Anti-inflammatory evaluation of Coronopus didymus in the pleurisy and paw oedema models in mice.

AbstractETHNOPHARMACOLOGICAL RELEVANCE:
Mastrunço (Coronopus didymus--CD) is currently considered as a medicinal specie often used in Brazil, especially in southeast region, for the treatment of several diseases in which pain and inflammation are common. Treatment with the plant can be done by infusion, decoction, or through food. The aim of this study was: to investigate the anti-inflammatory effect of hydroalcoholic extract obtained from the leaves of CD following the traditional procedure.
MATERIALS AND METHODS:
The anti-inflammatory activity was determined using mouse of pleurisy and paw oedema models, both process being induced by different flogistic agents such as: carrageenan (Cg), bradykinin (BK), histamine (HIS), substance P (SP), dextran (DEX) or prostaglandin E(2) (PGE(2)). We evaluated the effect of CD (200-600 mg/kg) administered by oral route (p.o.) upon leukocytes migration, myeloperoxidase (MPO), and adenosine-deaminase (ADA) activities and nitric oxide (NO) levels.
RESULTS:
CD (200-600 mg/kg) inhibited the leukocytes by 60.0+/-1.42%, neutrophils by 82.75+/-1.29%, MPO by 42.30+/-4.23%, and ADA activities by 57.89+/-1.94%, as well as NO levels by 64.28+/-2.15% in Cg induced pleurisy. CD also inhibited total and differential leukocytes in the pleurisy induced by BK (1.30+/-0.11/0.29+/-0.02), HIS (1.20+/-0.09/0.42+/-0.05) and SP (0.74+/-0.06/0.14+/-0.01). In addition, CD was effective in reducing paw oedema induced by Cg by 72.79+/-1.13%, SP by 68.26.+/-0.78%, BK by 66.66.+/-0.77%, PGE(2) by 53.346.+/-1.18 and DEX by 65.14+/-2.35%.
CONCLUSION:
Several mechanisms, including the inhibition of enzymes (MPO and ADA) and mediators (BK, HIS, SP, NO and PGE(2)) release and/or action, appear to account for the anti-inflammatory effect of Coronopus didymus.
AuthorsTereza Cristina Pamplona Mosimann Busnardo, Cristina Padoani, Ticiana Camila Mora, Maique Weber Biavatti, Tânia Silvia Fröde, Cristiani Bürger, Vanessa D Claudino, Eduardo Monguilhote Dalmarco, Márcia Maria de Souza
JournalJournal of ethnopharmacology (J Ethnopharmacol) Vol. 128 Issue 2 Pg. 519-25 (Mar 24 2010) ISSN: 1872-7573 [Electronic] Ireland
PMID20026396 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents
  • Nitric Oxide
  • Substance P
  • Histamine
  • Carrageenan
  • Peroxidase
  • Adenosine Deaminase
  • Bradykinin
Topics
  • Adenosine Deaminase (pharmacology)
  • Animals
  • Anti-Inflammatory Agents (administration & dosage)
  • Bradykinin (pharmacology)
  • Brazil
  • Carrageenan (pharmacology)
  • Edema (chemically induced, drug therapy)
  • Histamine (pharmacology)
  • Inflammation (chemically induced, drug therapy)
  • Leukocyte Count
  • Leukocytes (drug effects)
  • Mice
  • Neutrophils (drug effects)
  • Nitric Oxide (pharmacology)
  • Peroxidase (pharmacology)
  • Plant Leaves (chemistry)
  • Pleurisy (chemically induced, drug therapy)
  • Rats
  • Substance P (pharmacology)

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