HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

CCR6 ligands inhibit HIV by inducing APOBEC3G.

Abstract
We have identified a post-entry CCR6-dependent mechanism of inhibition of HIV occurring at an early stage of infection mediated by the induction of the host restriction factor apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G). We observed induction of APOBEC3G expression only in CCR6(+) cells but not in cells treated with the G inhibitory (Gi) pathway inhibitor pertussis toxin. CCR6 is highly expressed on peripheral blood CD4(+)CCR5(+) memory T cells and by 2 populations of CD4(+) T cells within the gut, alpha4beta7(+) and T helper type 17, that have been implicated in cell-to-cell spread of HIV and enhanced restoration of CD4(+) T cells within gut-associated lymphoid tissue, respectively. This novel CCR6-mediated mechanism of inhibition allows the identification of pathways that induce intrinsic immunity to HIV, which could be useful in devising novel therapeutics that selectively target CCR6(+) cells.
AuthorsMark K Lafferty, Lingling Sun, Leon DeMasi, Wuyuan Lu, Alfredo Garzino-Demo
JournalBlood (Blood) Vol. 115 Issue 8 Pg. 1564-71 (Feb 25 2010) ISSN: 1528-0020 [Electronic] United States
PMID20023216 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • Apolipoproteins B
  • CCR6 protein, human
  • Receptors, CCR5
  • Receptors, CCR6
  • Pertussis Toxin
  • APOBEC-3G Deaminase
  • APOBEC3G protein, human
  • Cytidine Deaminase
Topics
  • APOBEC-3G Deaminase
  • Apolipoproteins B (biosynthesis, immunology)
  • Cytidine Deaminase (immunology)
  • Enzyme Induction (drug effects, immunology)
  • HIV (immunology, metabolism)
  • HIV Infections (immunology, transmission)
  • Humans
  • Pertussis Toxin (pharmacology)
  • Receptors, CCR5 (immunology, metabolism)
  • Receptors, CCR6 (immunology, metabolism)
  • T-Lymphocytes, Helper-Inducer (immunology, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: