HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Non-diabetic metabolic syndrome and obesity do not affect serum paraoxonase and arylesterase activities but do affect oxidative stress and inflammation.

AbstractOBJECTIVE:
Paraoxonase-1 (PON-1), which has PON and arylesterase activities, is a high-density lipoprotein (HDL)-bound antioxidant enzyme that inhibits atherosclerosis. Diabetes has been shown to have an impact on oxidative stress. The effect of metabolic syndrome (MetS) on oxidative stress and PON-1 has been shown before, and PON-1 has been found to be related with accelerated atherogenesis. This study aimed to determine the oxidative state and PON and arylesterase activities in non-diabetic MetS and non-MetS obese patients.
DESIGN:
Thirty obese patients (3 M and 27 F) without MetS, 40 non-diabetic obese patients (3 M and 37 F) with MetS, and 30 controls (2 M and 28 F) were enrolled.
METHODS:
A 75 g glucose tolerance test was performed. PON-1, PON, arylesterase, total antioxidant status (TAS), high-sensitive C-reactive protein (hsCRP), and metabolic parameters were analyzed.
RESULTS:
PON and arylesterase activities were similar between the groups, while TAS was low in both MetS and obese groups compared to controls (P<0.01 and P<0.05 respectively). CRP was higher in the MetS group compared with the obese and control groups (P<0.01 and P<0.001 respectively). In both the obese and MetS groups, CRP showed a positive correlation with body mass index (BMI). TAS was negatively correlated with BMI, waist circumference, triglyceride levels, and systolic and diastolic blood pressures (P<0.001).
CONCLUSIONS:
Oxidative stress is altered in non-diabetic MetS and non-MetS obese patients, but PON and arylesterase activities seem not to be affected. This result may be due to the absence of diabetes, the most severe form of altered carbohydrate metabolism.
AuthorsSuzan Tabur, Ayse Nur Torun, Tevfik Sabuncu, Mehmet Nuri Turan, Hakim Celik, Ali Riza Ocak, Nurten Aksoy
JournalEuropean journal of endocrinology (Eur J Endocrinol) Vol. 162 Issue 3 Pg. 535-41 (Mar 2010) ISSN: 1479-683X [Electronic] England
PMID20022940 (Publication Type: Journal Article)
Chemical References
  • Antioxidants
  • Blood Glucose
  • Lipids
  • Carboxylic Ester Hydrolases
  • arylesterase
  • Aryldialkylphosphatase
Topics
  • Adult
  • Analysis of Variance
  • Antioxidants (metabolism)
  • Aryldialkylphosphatase (blood)
  • Blood Glucose (metabolism)
  • Blood Pressure (physiology)
  • Body Mass Index
  • Carboxylic Ester Hydrolases (blood)
  • Female
  • Glucose Tolerance Test
  • Humans
  • Inflammation (metabolism)
  • Lipids (blood)
  • Male
  • Metabolic Syndrome (metabolism)
  • Obesity (metabolism)
  • Oxidative Stress (physiology)
  • Regression Analysis
  • Waist Circumference

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: