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NMDA NR2B subtype-selective receptor antagonists fail to antagonize electrically-precipitated seizures and elicit popping in mice.

Abstract
NR2B-subtype-selective antagonists differ from MK-801, a nonselective NMDA receptor antagonist. MK-801 antagonizes electrical seizures at doses as low as 0.1 to 0.18mg/kg and elicits popping at doses as low as 0.5mg/kg, whereas ifenprodil and Ro 8-4304 were unable to do so at the doses tested. Ro 25-6981, however, was able to antagonize electrically-precipitated tonic hindlimb extension at 100mg/kg, but was not able to elicit popping behavior at this dose.
AuthorsJessica A Burket, John Mastropaolo, Richard B Rosse, Elionora U Katz, Stephen I Deutsch
JournalEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology (Eur Neuropsychopharmacol) Vol. 20 Issue 3 Pg. 207-10 (Mar 2010) ISSN: 1873-7862 [Electronic] Netherlands
PMID20022475 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
CopyrightCopyright 2009 Elsevier B.V. All rights reserved.
Chemical References
  • NR2B NMDA receptor
  • Phenols
  • Piperidines
  • Receptors, N-Methyl-D-Aspartate
  • Ro 25-6981
Topics
  • Animals
  • Dose-Response Relationship, Drug
  • Electroshock (methods)
  • Male
  • Mice
  • Phenols (pharmacology)
  • Piperidines (pharmacology)
  • Receptors, N-Methyl-D-Aspartate (antagonists & inhibitors, metabolism)
  • Seizures (metabolism, prevention & control)

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