Abstract |
NR2B-subtype-selective antagonists differ from MK-801, a nonselective NMDA receptor antagonist. MK-801 antagonizes electrical seizures at doses as low as 0.1 to 0.18mg/kg and elicits popping at doses as low as 0.5mg/kg, whereas ifenprodil and Ro 8-4304 were unable to do so at the doses tested. Ro 25-6981, however, was able to antagonize electrically-precipitated tonic hindlimb extension at 100mg/kg, but was not able to elicit popping behavior at this dose.
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Authors | Jessica A Burket, John Mastropaolo, Richard B Rosse, Elionora U Katz, Stephen I Deutsch |
Journal | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
(Eur Neuropsychopharmacol)
Vol. 20
Issue 3
Pg. 207-10
(Mar 2010)
ISSN: 1873-7862 [Electronic] Netherlands |
PMID | 20022475
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | Copyright 2009 Elsevier B.V. All rights reserved. |
Chemical References |
- NR2B NMDA receptor
- Phenols
- Piperidines
- Receptors, N-Methyl-D-Aspartate
- Ro 25-6981
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Topics |
- Animals
- Dose-Response Relationship, Drug
- Electroshock
(methods)
- Male
- Mice
- Phenols
(pharmacology)
- Piperidines
(pharmacology)
- Receptors, N-Methyl-D-Aspartate
(antagonists & inhibitors, metabolism)
- Seizures
(metabolism, prevention & control)
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