Abstract | PURPOSE: MATERIALS AND METHODS: RESULTS: For cumulative administration SC-560 (0.3 mg/kg), rofecoxib (0.3 mg/kg) and FYO-750 (0.1 to 1 mg/kg) significantly increased bladder capacity. For single administration neither SC-560 (0.03 mg/kg) nor rofecoxib (0.03 mg/kg) affected bladder capacity but SC-560 plus rofecoxib significantly increased bladder capacity vs vehicle. Intracerebroventricular and intrathecal administration of FYO-750 did not affect bladder capacity. FYO-750 did not affect urinary production in diuretic rats and the effects of FYO-750 were blocked by resiniferatoxin except at the highest drug dose. CONCLUSIONS:
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Authors | Ippei Tanaka, Keiko Nagase, Kazuya Tanase, Yoshitaka Aoki, Hironobu Akino, Osamu Yokoyama |
Journal | The Journal of urology
(J Urol)
Vol. 183
Issue 2
Pg. 786-92
(Feb 2010)
ISSN: 1527-3792 [Electronic] United States |
PMID | 20022033
(Publication Type: Journal Article)
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Copyright | Copyright 2010 American Urological Association. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Cyclooxygenase Inhibitors
- Lactones
- Pyrazoles
- SC 560
- Sulfones
- rofecoxib
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Topics |
- Animals
- Cerebral Infarction
(complications)
- Cyclooxygenase Inhibitors
(pharmacology, therapeutic use)
- Female
- Lactones
(pharmacology, therapeutic use)
- Nerve Fibers, Unmyelinated
(drug effects)
- Pyrazoles
(pharmacology, therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Sulfones
(pharmacology, therapeutic use)
- Urinary Bladder, Neurogenic
(drug therapy, etiology)
- Urinary Bladder, Overactive
(drug therapy, etiology)
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