Modulatory effects of black tea polyphenols on rat forestomach carcinogenesis.

Abstract

ABSTRACT The present study was designed to evaluate the chemopreventive effects of black tea polyphenols (Polyphenon-B) on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis in Wistar rats. Intragastric administration of MNNG induced well-differentiated squamous cell carcinomas that showed diminished mitochondrial lipid and protein oxidation and an increase in antioxidants. In contrast to tumor tissue, the liver mitochondria of tumor-bearing animals showed elevated lipid and protein oxidation with compromised antioxidant defenses. Dietary administration of Polyphenon-B effectively suppressed MNNG-induced stomach tumors, modulated mitochondrial lipid and protein oxidation, and enhanced antioxidant enzyme activities in the stomach and liver. Our results suggest that Polyphenon-B may exert its chemopreventive effects by modulating mitochondrial cellular redox status in the tumor as well as in the host liver.

• Authors: R Senthil Murugan, K V P Chandra Mohan, S Nagini
• Journal: Toxicology mechanisms and methods (Toxicol Mech Methods) Vol. 17 Issue 8 Pg. 467-74 ( 2007) ISSN: 1537-6524 [Electronic] England
• PMID: 20020873 (Publication Type: Journal Article)