Efficacy and safety of anti-D for immune thrombocytopenic purpura in children.

This study was conducted in 20 children (16 males) (mean age 9.2 +/- 4.34y) with immune thrombocytopenic purpura (ITP) to assess the response to anti-D immunoglobulin. Six patients had newly diagnosed ITP, 6 had persistent ITP and 8 had chronic ITP. The overall response rate was 70% (14/20). The median time to response was 3 days (1-13 days). Response to anti-D was not related to age, sex, severity of bleeding, platelet counts at presentation, ABO blood group, or prior steroid or IVIG response.
AuthorsRahul Naithani, Rajat Kumar, M Mahapatra, Seema Tyagi, Pravas Mishra
JournalIndian pediatrics (Indian Pediatr) Vol. 47 Issue 6 Pg. 517-9 (Jun 2010) ISSN: 0974-7559 [Electronic] India
PMID20019392 (Publication Type: Journal Article)
Chemical References
  • Isoantibodies
  • RHO(D) antibody
  • Rho(D) Immune Globulin
  • Adolescent
  • Child
  • Child, Preschool
  • Cohort Studies
  • Female
  • Fever
  • Humans
  • Isoantibodies (administration & dosage, adverse effects, therapeutic use)
  • Male
  • Pharmacokinetics
  • Platelet Count
  • Purpura, Thrombocytopenic (drug therapy, epidemiology)
  • Rho(D) Immune Globulin

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