Abstract | RATIONALE: OBJECTIVES: METHODS: MEASUREMENTS AND MAIN RESULTS: CONCLUSIONS: This is the first study indicating that integrins modulate ASM remodeling in an animal model of allergic asthma, which can be inhibited by a small peptide containing the RGD motif.
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Authors | Bart G J Dekkers, I Sophie T Bos, Reinoud Gosens, Andrew J Halayko, Johan Zaagsma, Herman Meurs |
Journal | American journal of respiratory and critical care medicine
(Am J Respir Crit Care Med)
Vol. 181
Issue 6
Pg. 556-65
(Mar 15 2010)
ISSN: 1535-4970 [Electronic] United States |
PMID | 20019343
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies
- Biomarkers
- Oligopeptides
- Platelet Aggregation Inhibitors
- Proliferating Cell Nuclear Antigen
- arginyl-glycyl-aspartyl-serine
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Topics |
- Administration, Topical
- Airway Remodeling
(drug effects, immunology)
- Animals
- Antibodies
(immunology)
- Asthma
(immunology, physiopathology)
- Biomarkers
- Blotting, Western
- Cell Culture Techniques
- Cell Proliferation
(drug effects)
- Disease Models, Animal
- Fibrosis
(immunology)
- Guinea Pigs
- Humans
- Inflammation
(immunology)
- Male
- Muscle Contraction
(drug effects)
- Muscle, Smooth
(drug effects, immunology)
- Oligopeptides
(immunology, pharmacology)
- Platelet Aggregation Inhibitors
(immunology, pharmacology)
- Proliferating Cell Nuclear Antigen
(drug effects, immunology)
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