[Anti-ulcerative effect of non-starch polysaccharides].

Abstract

Standard models of experimental ulceration (of neurogenic origin, H. Shay ulcer, indomethacine-, ethanol-, prednisolone-, histamine- and acetate-induced ulcers) were used to demonstrate protective effect of non-starch polysaccharides (potassium alginate, potassium pectate, low-esterified pectin). Potassium pectate proved to be the most efficacious protector. Mechanism of its anti-ulcerative action is attributable to antacidic, cytoprotective, and reparative activity. It appeals to optimally stimulate the motor-evacuation function and, besides, exhibits marked anti-inflammatory activity.

• Authors: S G Krylova, L A Efimova, E P Zueva, Iu S Khotimchenko, T G Razina, E N Amosova, K A Lopatina, T I Fomina
• Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk (Vestn Ross Akad Med Nauk) Issue 11 Pg. 35-9 ( 2009) ISSN: 0869-6047 [Print] Russia (Federation)
• PMID: 20017406 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Alginates
• Antidiarrheals
• Biocompatible Materials
• Drug Carriers
• Hexuronic Acids
• Polysaccharides
• Pectins
• Glucuronic Acid

Topics

• Administration, Oral
• Alginates (administration & dosage, therapeutic use)
• Animals
• Antidiarrheals (administration & dosage, therapeutic use)
• Biocompatible Materials (administration & dosage, therapeutic use)
• Disease Models, Animal
• Drug Carriers
• Female
• Gastric Emptying (drug effects)
• Glucuronic Acid (administration & dosage, therapeutic use)
• Hexuronic Acids (administration & dosage, therapeutic use)
• Male
• Mice
• Pectins (administration & dosage, therapeutic use)
• Polysaccharides (administration & dosage, therapeutic use)
• Rats
• Rats, Wistar
• Stomach Ulcer (drug therapy, physiopathology)
• Treatment Outcome