Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma.

Abstract

PURPOSE:

The study aimed to analyze the expression of bone morphogenetic protein-2/4 (BMP-2/4) and its receptor BMPR-IA (BMP receptor type IA) in metastatic and nonmetastatic oral squamous cell carcinoma (OSCC) and its implications for disease prognosis.

MATERIALS AND METHODS:

The experimental group included 16 cases of OSCC without metastasis and 7 cases of OSCC with metastasis. The presence or absence of nodal metastasis was used as a parameter for the evaluation of disease prognosis. Ten cases of oral fibroepithelial hyperplasia were selected as the control group. The expression of BMP-2/4 and BMPR-IA was analyzed by immunohistochemistry.

RESULTS:

In the experimental group with metastasis, strong expression of BMP-2/4 was observed in most cases (71.4%), whereas BMPR-IA exhibited weak expression (85.7%). In the experimental group without metastasis, there was strong expression of BMP-2/4 (62.5%) and BMPR-IA (100%). A significant association was observed between the prognosis of OSCC and the intensity of BMP-2/4 staining (P = .002). Weak immunoreactivity to BMP-2/4 and BMPR-IA was observed in all control specimens.

CONCLUSIONS:

The results suggest that strong expression of BMP-2/4, associated with low expression of BMPR-IA, observed in metastatic OSCC has a prognostic value, with the loss of responsiveness to BMPs through the loss of expression of their receptors being indicative of the development of metastasis.

• Authors: Andréa Ferreira Soares, Ruth Lopes de Freitas Xavier, Márcia Cristina da Costa Miguel, Lélia Batista de Souza, Leão Pereira Pinto
• Journal: American journal of otolaryngology (Am J Otolaryngol) 2010 Jul-Aug Vol. 31 Issue 4 Pg. 266-71 ISSN: 1532-818X [Electronic] United States
• PMID: 20015767 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright 2010. Published by Elsevier Inc.

Chemical References

• Biomarkers, Tumor
• Bone Morphogenetic Protein 4
• Bone Morphogenetic Protein Receptors, Type I

Topics

• Biomarkers, Tumor (biosynthesis)
• Bone Morphogenetic Protein 4 (biosynthesis)
• Bone Morphogenetic Protein Receptors, Type I (biosynthesis)
• Carcinoma, Squamous Cell (metabolism, secondary)
• Disease Progression
• Humans
• Immunohistochemistry
• Mouth Neoplasms (metabolism, pathology)
• Neoplasm Metastasis
• Prognosis
• Retrospective Studies