Abstract |
In vivo optical imaging shows that a fluorescent imaging probe, comprised of a near-infrared fluorophore attached to an affinity group containing two zinc(II)-dipicolylamine (Zn-DPA) units, targets prostate and mammary tumors in two different xenograft animal models. The tumor selectivity is absent with control fluorophores whose structures do not have appended Zn-DPA targeting ligands. Ex vivo biodistribution and histological analyses indicate that the probe is targeting the necrotic regions of the tumors, which is consistent with in vitro microscopy showing selective targeting of the anionic membrane surfaces of dead and dying cells.
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Authors | Bryan A Smith, Walter J Akers, W Matthew Leevy, Andrew J Lampkins, Shuzhang Xiao, William Wolter, Mark A Suckow, Samuel Achilefu, Bradley D Smith |
Journal | Journal of the American Chemical Society
(J Am Chem Soc)
Vol. 132
Issue 1
Pg. 67-9
(Jan 13 2010)
ISSN: 1520-5126 [Electronic] United States |
PMID | 20014845
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2,2'-dipicolylamine
- Amines
- Fluorescent Dyes
- Organometallic Compounds
- Picolinic Acids
- Zinc
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Topics |
- Absorption
- Amines
(chemistry)
- Animals
- Breast Neoplasms
(pathology)
- Cell Line, Tumor
- Cell Survival
- Cell Transformation, Neoplastic
- Fluorescent Dyes
(chemical synthesis, chemistry, metabolism)
- Infrared Rays
- Male
- Mice
- Molecular Imaging
(methods)
- Organometallic Compounds
(chemical synthesis, chemistry, metabolism)
- Picolinic Acids
(chemistry)
- Prostatic Neoplasms
(pathology)
- Rats
- Zinc
(chemistry)
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