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Daptomycin use in a neonate: serum level monitoring and outcome.

Abstract
We present a case of successfully treated persistent bacteremia due to Gram-positive bacteria with daptomycin in a preterm neonate. Daptomycin was given at higher doses (6 mg/kg/dose) and shorter intervals (every 12 hours) than those recommended for adults with no adverse events. Peak and trough serum concentrations of daptomycin were 27.3 and 11.6 μg/mL [DOSAGE ERROR CORRECTED] at day 4 as well as 22.9 and 7.9 μg/mL [DOSAGE ERROR CORRECTED]at day 11 after initiation of treatment, respectively.
AuthorsKosmas Sarafidis, Elias Iosifidis, Evangelos Gikas, Maria Tsivitanidou, Vassiliki Drossou-Agakidou, Emmanuel Roilides
JournalAmerican journal of perinatology (Am J Perinatol) Vol. 27 Issue 5 Pg. 421-4 (May 2010) ISSN: 1098-8785 [Electronic] United States
PMID20013573 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright Thieme Medical Publishers.
Chemical References
  • Anti-Bacterial Agents
  • Daptomycin
Topics
  • Anti-Bacterial Agents (administration & dosage, blood)
  • Daptomycin (administration & dosage, blood)
  • Female
  • Gram-Positive Bacterial Infections (drug therapy)
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Male
  • Treatment Outcome

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