Abstract |
We present a case of successfully treated persistent bacteremia due to Gram-positive bacteria with daptomycin in a preterm neonate. Daptomycin was given at higher doses (6 mg/kg/dose) and shorter intervals (every 12 hours) than those recommended for adults with no adverse events. Peak and trough serum concentrations of daptomycin were 27.3 and 11.6 μg/mL [DOSAGE ERROR CORRECTED] at day 4 as well as 22.9 and 7.9 μg/mL [DOSAGE ERROR CORRECTED]at day 11 after initiation of treatment, respectively.
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Authors | Kosmas Sarafidis, Elias Iosifidis, Evangelos Gikas, Maria Tsivitanidou, Vassiliki Drossou-Agakidou, Emmanuel Roilides |
Journal | American journal of perinatology
(Am J Perinatol)
Vol. 27
Issue 5
Pg. 421-4
(May 2010)
ISSN: 1098-8785 [Electronic] United States |
PMID | 20013573
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright Thieme Medical Publishers. |
Chemical References |
- Anti-Bacterial Agents
- Daptomycin
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Topics |
- Anti-Bacterial Agents
(administration & dosage, blood)
- Daptomycin
(administration & dosage, blood)
- Female
- Gram-Positive Bacterial Infections
(drug therapy)
- Humans
- Infant, Newborn
- Infant, Premature
- Male
- Treatment Outcome
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