CXCL13 expression in Chlamydia trachomatis infection of the female reproductive tract.
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| Abstract |
Chlamydia trachomatis is the most common cause of acute salpingitis worldwide. The socioeconomic impact of sexually transmitted infections (STI) caused by C. trachomatis is considerable. The purpose of this study was to investigate secretion of a unique chemokine, CXCL13, during the inflammatory process in human fallopian tube tissue in response to infection with C. trachomatis. We employed two models for our experiments: archived fallopian tube paraffin sections from known cases of salpingitis of unknown etiology and human fallopian tube organ culture established from fresh fallopian tube biopsies subsequently infected in vitro with C. trachomatis serovar E. We used immunohistochemistry, microarray analysis and cytometric bead array to study these specimens. In both models, we found that the fallopian tissue infected with C. trachomatis expressed CXCL13 and other characteristics of tertiary lymphoid tissue. In addition, we found that CXCL13 was expressed in multiple cell types, including endothelial cells, demonstrating a mechanism for the lymphoid aggregation seen in fallopian tube tissue during salpingitis and infection with C. trachomatis.
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| Authors | M King, H Poya, J Rao, S Natarajan, A W Butch, N Aziz, S Kok, M H Chang, J M Lyons, K Ault, K A Kelly |
| Journal | Drugs of today (Barcelona, Spain : 1998) (Drugs Today (Barc)) Vol. 45 Suppl B Pg. 125-34 (Nov 2009) ISSN: 1699-3993 [Print] Spain |
| PMID | 20011704 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't) |
| Copyright | Copyright 2009 Prous Science, S.A.U. or its licensors. All rights reserved. |
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