Abstract | PURPOSE: METHODS: RESULTS: No significant difference was detected between the primary tumor and liver metastasis in expression pattern of cancer/testis antigen genes in colorectal cancer tissue samples. However, 3 cancer/testis antigen genes (PAGE4, SCP-1, and SPANX) and 3 clinicopathologic parameters (lymph node involvement, vessel cancer embolus, and tumor invasion depth) correlated significantly with liver metastasis of colorectal cancer (P < .05). A logistic regression model was constructed for prediction of liver metastasis based on a panel consisting of PAGE4, lymph node involvement, and presence or absence of vessel cancer embolus. The predicted risk of liver metastasis based on the panel was consistent with the actual risk observed. The probability of developing liver metastasis as estimated by the panel was 86.9% when all 3 factors were positive, representing an up to 20% improvement in the prediction level compared with the classic methods of lymph node involvement and vessel cancer embolus. CONCLUSIONS:
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Authors | ZhiGuo Chen, Ming Li, YanHua Yuan, Qi Wang, Li Yan, Jin Gu |
Journal | Diseases of the colon and rectum
(Dis Colon Rectum)
Vol. 53
Issue 1
Pg. 31-8
(Jan 2010)
ISSN: 1530-0358 [Electronic] United States |
PMID | 20010347
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, Neoplasm
- Biomarkers, Tumor
- Nuclear Proteins
- PAGE4 protein, human
- SCP 1
- SPANXA1 protein, human
- Acetaminophen
- Saccharin
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Topics |
- Acetaminophen
(analogs & derivatives)
- Adult
- Aged, 80 and over
- Antigens, Neoplasm
(genetics)
- Biomarkers, Tumor
(genetics)
- Colorectal Neoplasms
(genetics, pathology)
- Female
- Humans
- Liver Neoplasms
(genetics, secondary)
- Logistic Models
- Male
- Middle Aged
- Nuclear Proteins
(genetics)
- Risk Factors
- Saccharin
(analogs & derivatives)
- Young Adult
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