Dydrogesterone support in threatened miscarriage.

Abstract

INTRODUCTION:

The aim of this study was to determine whether dydrogesterone helps to preserve pregnancy in women with threatened miscarriage.

METHODS:

146 women who presented with mild or moderate vaginal bleeding during the first trimester of pregnancy were randomised to receive oral dydrogesterone (10mg b.i.d.) (n=86) or no treatment (n=60). Dydrogesterone was continued until 1 week after the bleeding had stopped. All women received standard supportive care.

RESULTS:

The incidence of miscarriage was significantly lower in the dydrogesterone group than in the untreated group (17.5% vs. 25%; p<0.05). There were no statistically significant differences between the groups with respect to pregnancy complications or congenital abnormalities.

CONCLUSION:

Dydrogesterone appears to have beneficial effects in women with threatened miscarriage.

• Authors: Mazen Y El-Zibdeh, Lama T Yousef
• Journal: Maturitas (Maturitas) Vol. 65 Suppl 1 Pg. S43-6 (Dec 2009) ISSN: 1873-4111 [Electronic] Ireland
• PMID: 20007011 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Progestins
• Reproductive Control Agents
• Dydrogesterone

Topics

• Abortion, Spontaneous (epidemiology, prevention & control)
• Abortion, Threatened (drug therapy)
• Adult
• Congenital Abnormalities (epidemiology)
• Dydrogesterone (therapeutic use)
• Female
• Humans
• Incidence
• Pregnancy
• Pregnancy Complications (epidemiology)
• Progestins (therapeutic use)
• Reproductive Control Agents (therapeutic use)
• Young Adult