Abstract |
Antiretroviral therapy (ART) preserves kidney function in patients with human immunodeficiency virus ( HIV)-associated nephropathy (HIVAN). Emerging data also document substantial renal benefits of ART in the general HIV-infected population, which is associated in part with suppression of HIV-1 viral replication. The extent to which the response to ART differs in persons with HIVAN compared with those with other HIV-associated kidney disorders is unknown. Beneficial effects of corticosteroids and angiotensin-converting enzyme inhibitors on kidney function also are suggested by retrospective cohort studies and uncontrolled trials of patients with HIVAN. Underexposure to ART or inadequate ART dosing in HIV-infected patients with CKD may curtail the optimal benefits that may be derived from this therapy.
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Authors | Robert C Kalayjian |
Journal | Advances in chronic kidney disease
(Adv Chronic Kidney Dis)
Vol. 17
Issue 1
Pg. 59-71
(Jan 2010)
ISSN: 1548-5609 [Electronic] United States |
PMID | 20005490
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Chemical References |
- Adrenal Cortex Hormones
- Angiotensin-Converting Enzyme Inhibitors
- Anti-Retroviral Agents
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Topics |
- AIDS-Associated Nephropathy
(drug therapy)
- Adrenal Cortex Hormones
(therapeutic use)
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Anti-Retroviral Agents
(therapeutic use)
- Humans
- Kidney
(drug effects)
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