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The treatment of HIV-associated nephropathy.

Abstract
Antiretroviral therapy (ART) preserves kidney function in patients with human immunodeficiency virus (HIV)-associated nephropathy (HIVAN). Emerging data also document substantial renal benefits of ART in the general HIV-infected population, which is associated in part with suppression of HIV-1 viral replication. The extent to which the response to ART differs in persons with HIVAN compared with those with other HIV-associated kidney disorders is unknown. Beneficial effects of corticosteroids and angiotensin-converting enzyme inhibitors on kidney function also are suggested by retrospective cohort studies and uncontrolled trials of patients with HIVAN. Underexposure to ART or inadequate ART dosing in HIV-infected patients with CKD may curtail the optimal benefits that may be derived from this therapy.
AuthorsRobert C Kalayjian
JournalAdvances in chronic kidney disease (Adv Chronic Kidney Dis) Vol. 17 Issue 1 Pg. 59-71 (Jan 2010) ISSN: 1548-5609 [Electronic] United States
PMID20005490 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
Chemical References
  • Adrenal Cortex Hormones
  • Angiotensin-Converting Enzyme Inhibitors
  • Anti-Retroviral Agents
Topics
  • AIDS-Associated Nephropathy (drug therapy)
  • Adrenal Cortex Hormones (therapeutic use)
  • Angiotensin-Converting Enzyme Inhibitors (therapeutic use)
  • Anti-Retroviral Agents (therapeutic use)
  • Humans
  • Kidney (drug effects)

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