Abstract |
The efficacy of azacitidine, a cytosine nucleoside analog, has been demonstrated in two large phase III trials in myelodysplastic syndromes (MDS) patients, primarily in higher-risk patients. In the Cancer and Leukemia Group B (CALGB) study (lower-and higher-risk MDS patients; n = 191) azacitidine significantly prolonged median time-to-progression to acute myeloid leukemia or death (21 vs 13 months for supportive care; p = 0.007). The AZA-001 trial (Intermediate-2-and High-risk MDS patients; n = 358) showed azacitidine significantly prolonged median overall survival compared with conventional care regimens (24.5 vs 15.0 months; p = 0.0001). These results establish azacitidine as a reference first-line treatment in patients with Intermediate-2-and High-risk MDS who are not immediate candidates for allogeneic stem cell transplantation.
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Authors | Pierre Fenaux, Lionel Ades |
Journal | Leukemia research
(Leuk Res)
Vol. 33 Suppl 2
Pg. S7-11
(Dec 2009)
ISSN: 1873-5835 [Electronic] England |
PMID | 20004796
(Publication Type: Journal Article, Review)
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Chemical References |
- Antimetabolites, Antineoplastic
- Azacitidine
|
Topics |
- Aged
- Antimetabolites, Antineoplastic
(therapeutic use)
- Azacitidine
(therapeutic use)
- Clinical Trials as Topic
- Female
- Humans
- Male
- Myelodysplastic Syndromes
(drug therapy)
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