Colistimethate sodium therapy for multidrug-resistant isolates in pediatric patients.

Abstract

AIM:

The aim of the present study was to assess the efficacy and safety of colistimethate sodium therapy in multidrug-resistant nosocomial infections caused by Pseudomonas aeruginosa or Acinetobacter baumannii in neonates and children.

METHODS:

Pediatric patients hospitalized at the Uludag University Hospital who had nosocomial infections caused by multidrug-resistant P. aeruginosa or A. baumannii, were enrolled in the study. Colistimethate sodium at a dosage of 50-75 x 10(3) U/kg per day was given i.v. divided into three doses.

RESULTS:

Fifteen patients received 17 courses of colistimethate sodium for the following infections: ventilator-associated pneumonia (n= 14), catheter-related sepsis (n= 1) and skin and soft-tissue infection (n= 2). The mean age of patients was 53.2 + 74.7 months (range, 8 days-15 years) and 60% were male. Mortality was 26.6%.

CONCLUSION:

Colistimethate sodium appears to be safe and effective for the treatment of severe infections caused by multidrug-resistant P. aeruginosa or A. baumannii in pediatric patients.

• Authors: Solmaz Celebi, Mustafa Hacimustafaoglu, Nilgun Koksal, Hilal Ozkan, Merih Cetinkaya
• Journal: Pediatrics international : official journal of the Japan Pediatric Society (Pediatr Int) Vol. 52 Issue 3 Pg. 410-4 (Jun 2010) ISSN: 1442-200X [Electronic] Australia
• PMID: 20003141 (Publication Type: Journal Article)

Chemical References

• colistinmethanesulfonic acid
• Colistin

Topics

• Acinetobacter Infections (diagnosis, drug therapy)
• Acinetobacter baumannii (drug effects, isolation & purification)
• Adolescent
• Child
• Child, Preschool
• Colistin (analogs & derivatives, pharmacology, therapeutic use)
• Cross Infection (drug therapy, microbiology)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Drug Resistance, Multiple, Bacterial
• Female
• Follow-Up Studies
• Hospitals, University
• Humans
• Infant
• Infant, Newborn
• Injections, Intravenous
• Intensive Care Units, Neonatal
• Intensive Care Units, Pediatric
• Male
• Microbial Sensitivity Tests
• Prospective Studies
• Pseudomonas Infections (diagnosis, drug therapy)
• Pseudomonas aeruginosa (drug effects, isolation & purification)
• Statistics, Nonparametric
• Treatment Outcome
• Turkey