Unusual presentation of chromoblastomycosis due to Cladophialophora carrionii in a renal and pancreas transplant recipient patient successfully treated with posaconazole and surgical excision.

Abstract

Chromoblastomycosis is a chronic, tropical and subtropical, subcutaneous mycosis caused by inoculation of dematiaceous molds. This disease is uncommonly reported in patients who have undergone solid organ transplantation. We describe a case of chromoblastomycosis caused by Cladophialophora carrionii that occurred 7 years after transplantation in a 58-year-old male renal and pancreatic transplant recipient. Diagnosis was based on histopathology and isolation of multiple colonies of the dematiaceous mold in pure culture. Identification was achieved by sequencing of the internal transcribed spacer regions of the rRNA. The patient was successfully treated with posaconazole and surgical excision of a residual lesion.

• Authors: C Dupont, T A Duong, S Mallet, M F Mamzer-Bruneel, E Thervet, M E Bougnoux, B Dupont
• Journal: Transplant infectious disease : an official journal of the Transplantation Society (Transpl Infect Dis) Vol. 12 Issue 2 Pg. 180-3 (Apr 2010) ISSN: 1399-3062 [Electronic] Denmark
• PMID: 20002358 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Triazoles
• posaconazole

Topics

• Antifungal Agents (therapeutic use)
• Ascomycota
• Chromoblastomycosis (drug therapy, etiology, surgery)
• Humans
• Immunocompromised Host
• Kidney Transplantation
• Male
• Middle Aged
• Pancreas Transplantation
• Treatment Outcome
• Triazoles (therapeutic use)