Crystal structure of bucain, a three-fingered toxin from the venom of the Malayan krait (Bungarus candidus).

Abstract

Bucain, a potent neurotoxin isolated from the venom of the Malayan krait (Bungarus candidus), induces paralysis and death. Its crystal structure has been determined at 2.10 A resolution and based on the molecular topology and hydrophobicity profile is structurally classified as a three-fingered alpha-neurotoxin possessing a positively charged AChR-binding site.

• Authors: M T Murakami, R M Kini, R K Arni
• Journal: Protein and peptide letters (Protein Pept Lett) Vol. 16 Issue 12 Pg. 1473-7 ( 2009) ISSN: 1875-5305 [Electronic] Netherlands
• PMID: 20001910 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Bungarotoxins
• Elapid Venoms
• Neurotoxins
• Receptors, Cholinergic
• Toxins, Biological
• bucain
• bucandin

Topics

• Amino Acid Sequence
• Animals
• Binding Sites
• Bungarotoxins (chemistry, isolation & purification, metabolism)
• Bungarus (metabolism)
• Crystallization
• Crystallography, X-Ray
• Elapid Venoms (chemistry, isolation & purification, metabolism)
• Molecular Sequence Data
• Neurotoxins (chemistry, isolation & purification, metabolism)
• Protein Structure, Secondary
• Receptors, Cholinergic (metabolism)
• Sequence Alignment
• Toxins, Biological (chemistry, isolation & purification, metabolism)