Abstract | AIMS: Toker cells (TCs) are normal components of the nipple epidermis. Because of their morphological and immunohistochemical similarities to mammary Paget cells (PCs), their presence may lead to a mistaken diagnosis of Paget's disease. The objective of this study was to identify immunohistochemical markers that are able to distinguish TCs from mammary PCs. METHODS: RESULTS: TCs were consistently positive for CK7 and ER but negative for c-erbB-2. TCs either did not express Ki-67 or expressed very low levels with only 1-3 positive cells per high-power field. In contrast, MPD tended strongly to express both Ki-67 and c-erbB-2. CONCLUSIONS: Results suggested that TCs and mammary PCs differ substantially in their expression of ER, c-erbB-2 and Ki-67, although they share immunoreactivity to CK7. Both Ki-67 and c-erbB-2 were consistently positive in mammary PCs but almost always negative in TCs, while ER was consistently positive in TCs. Therefore, a combination of these markers may allow TCs to be distinguished from mammary PCs.
|
Authors | Sanghui Park, Yeon-Lim Suh |
Journal | Pathology
(Pathology)
Vol. 41
Issue 7
Pg. 640-4
( 2009)
ISSN: 1465-3931 [Electronic] England |
PMID | 20001343
(Publication Type: Journal Article)
|
Chemical References |
- Biomarkers, Tumor
- Keratin-7
- Receptors, Estrogen
- Receptor, ErbB-2
|
Topics |
- Biomarkers, Tumor
(metabolism)
- Breast Neoplasms
(diagnosis, metabolism)
- Carcinoma, Ductal, Breast
(metabolism, pathology, surgery)
- Carcinoma, Intraductal, Noninfiltrating
(metabolism, pathology, surgery)
- Diagnosis, Differential
- Diagnostic Errors
(prevention & control)
- Epithelial Cells
(metabolism, pathology)
- Female
- Humans
- Immunohistochemistry
- Keratin-7
(metabolism)
- Mastectomy, Radical
- Neoplasms, Multiple Primary
- Nipples
(metabolism, pathology)
- Paget's Disease, Mammary
(diagnosis, metabolism)
- Receptor, ErbB-2
(metabolism)
- Receptors, Estrogen
(metabolism)
|