Abstract | BACKGROUND: OBJECTIVE: METHODS: Sixteen patients with resistant seborrheic dermatitis of the face applied pimecrolimus 1% cream twice daily for 2 weeks. The lesions were assessed clinically and the severity of the signs were assessed using a 4-point score. Additionally, the scores of all affected regions (paranasal, forehead, and eyebrows) were evaluated separately to assess whether different results would be obtained in different regions of the face. Also, patients completed self-assessments on a 100 mm Visual Analogue Scale (VAS) at each visit. RESULTS: Statistically significant reductions in the scores of all parameters were observed at day 7 and day 14 of the study. There were no significant differences between the responses on the three regions of the face. No adverse effects were reported except for temporary pruritus immediately after the application of pimecrolimus 1% cream in one patient. CONCLUSION: Although the interpretation of efficacy was limited by the open-label, non-controlled study design and the small number of patients, this trial suggests that pimecrolimus 1% cream may be a successful treatment choice for patients with resistant seborrheic dermatitis of the face.
|
Authors | Muge Guler Ozden, Nilgun Solak Tekin, Nilsel Ilter, Handan Ankarali |
Journal | American journal of clinical dermatology
(Am J Clin Dermatol)
Vol. 11
Issue 1
Pg. 51-4
( 2010)
ISSN: 1175-0561 [Print] New Zealand |
PMID | 20000875
(Publication Type: Clinical Trial, Journal Article)
|
Chemical References |
- Dermatologic Agents
- pimecrolimus
- Tacrolimus
|
Topics |
- Administration, Cutaneous
- Adult
- Aged
- Dermatitis, Seborrheic
(drug therapy, pathology)
- Dermatologic Agents
(administration & dosage)
- Face
(pathology)
- Female
- Humans
- Male
- Middle Aged
- Patient Satisfaction
- Retrospective Studies
- Sample Size
- Severity of Illness Index
- Tacrolimus
(administration & dosage, analogs & derivatives)
- Time Factors
- Treatment Outcome
|