Drug-induced liver injury caused by the histrelin (Vantus) subcutaneous implant.

Abstract

Drug-induced liver injury (DILI) is the leading cause of acute hepatic failure in the United States. Up to 13% of acute liver failure cases occur due to drugs other than acetaminophen. This clinical diagnosis, made after other causes of liver injury have been excluded, requires establishing a causal relationship between drug exposure and liver injury. The case of a patient with liver injury following a subcutaneous histrelin (Vantus) implant as therapy for advanced prostate cancer is presented.

• Authors: Jonathan M Ricker, William F Foody, Nathan M Shumway, Janet C Shaw
• Journal: Southern medical journal (South Med J) Vol. 103 Issue 1 Pg. 84-6 (Jan 2010) ISSN: 1541-8243 [Electronic] United States
• PMID: 19996852 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents, Hormonal
• Drug Implants
• Gonadotropin-Releasing Hormone
• histrelin

Topics

• Aged
• Antineoplastic Agents, Hormonal (administration & dosage, adverse effects)
• Chemical and Drug Induced Liver Injury (etiology)
• Drug Implants
• Gonadotropin-Releasing Hormone (administration & dosage, adverse effects, analogs & derivatives)
• Humans
• Male