Recurrent neuromyelitis optica in Brazilian patients: clinical, immunological, and neuroimaging characteristics.
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| Abstract |
Neuromyelitis optica has not been thoroughly studied in Brazilian patients following the discovery of NMO-IgG and its specific antigen aquaporin-4. In this study we aimed to describe the clinical NMO-IgG immunological status and neuroimaging characteristics of recurrent neuromyelitis optica in a series Brazilian patients. We undertook a retrospective study of 28 patients with recurrent neuromyelitis optica, according to 1999 Wingerchuk's diagnostic criteria. Data on NMO-IgG status, clinical features, and MRI findings were analyzed. Three men and 25 women were evaluated. Median age at onset of disease was 26 years (range 7-55); median time of follow-up was 7 years (range 2-14). The mean time elapsed between the first and the second attack was 17 months (median 8.5; range 2-88). NMO-IgG was detected in 18 patients (64.3%). Four patients died due to respiratory failure. Most patients presented with cervical (36%) and cervical-thoracic myelitis (46.4%). Holocord lesion was the most common pattern of involvement (50%) on the axial plane. We did not find a statistical association between myelitis extension and NMO-IgG result. Our series of Brazilian patients showed a younger age of onset than previously reported. In our series, in contrast to previous reports, there was no correlation between the extension of myelitis and NMO-IgG positivity.
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| Authors | T Adoni, A M M Lino, P D da Gama, S L Apóstolos-Pereira, P E Marchiori, F Kok, D Callegaro |
| Journal | Multiple sclerosis (Houndmills, Basingstoke, England) (Mult Scler) Vol. 16 Issue 1 Pg. 81-6 (Jan 2010) ISSN: 1477-0970 [Electronic] England |
| PMID | 19995833 (Publication Type: Journal Article) |
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