Abstract |
We evaluated both the short-and long-term efficacy of micafungin in patients with chronic pulmonary aspergillosis (CPA). We treated 26 patients with CPA, 19 with chronic necrotizing pulmonary aspergillosis (CNPA) and 7 with aspergilloma, with micafungin between February 2003 and September 2005. On completion of treatment (short-term efficacy evaluation), the efficacy rates of micafungin for CNPA and aspergilloma were 52.6% (10/19) and 71.4% (5/7), respectively, and the overall efficacy rate was 57.7% (15/26). Long-term efficacy was evaluable in 25 of 26 patients, and 15 patients, who responded favorably to micafungin, received maintenance therapy with itraconazole (200mg). In long-term efficacy evaluation, 10 patients were unchanged, but in 5 patients symptoms were exacerbated after 1.8 months (median time). This result suggests that establishing effective maintenance therapy, as well as acute-phase therapy, is important in the treatment of patients with CPA.
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Authors | Shigeo Yasuda, Ryoko Ohnishi, Toshitaka Suzuki, Kimiyasu Sano, Tatuo Kato |
Journal | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society
(Nihon Kokyuki Gakkai Zasshi)
Vol. 47
Issue 11
Pg. 985-90
(Nov 2009)
ISSN: 1343-3490 [Print] Japan |
PMID | 19994592
(Publication Type: Journal Article)
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Chemical References |
- Antifungal Agents
- Echinocandins
- Lipopeptides
- Itraconazole
- Micafungin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antifungal Agents
(therapeutic use)
- Chronic Disease
- Echinocandins
(therapeutic use)
- Female
- Humans
- Itraconazole
(administration & dosage)
- Lipopeptides
(therapeutic use)
- Male
- Micafungin
- Middle Aged
- Pulmonary Aspergillosis
(drug therapy)
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