Abstract |
Akt mediates survival signals which preserve various cancer cells from apoptosis. Its correlation with chemoresistance of cancer cells has attracted much attention. But how Akt affects vincristine-induced cell death in retinoblastoma is unknown. Here we show that Akt activity is involved in vincristine-induced cytotoxicity in retinoblastoma SO-Rb50 cells. Inhibition of Akt can decrease the survival of both sensitive and vincristine-resistant SO-Rb50 cells and increase the sensitivity of both cell lines to vincristine by enhancing the cell apoptosis and increasing the cellular accumulation of the drug. Akt may be a target for reducing drug resistance that improves the treatment for retinoblastoma.
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Authors | Hao Zhang, Bin Li, Shu-wei Bai, Hui-juan Wang |
Journal | Cancer investigation
(Cancer Invest)
Vol. 28
Issue 2
Pg. 156-65
(Feb 2010)
ISSN: 1532-4192 [Electronic] England |
PMID | 19968493
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Vincristine
- Proto-Oncogene Proteins c-akt
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Topics |
- Cell Cycle
- Cell Death
- Cell Line, Tumor
- Drug Resistance, Neoplasm
- Humans
- Proto-Oncogene Proteins c-akt
(metabolism)
- Retinal Neoplasms
(metabolism)
- Retinoblastoma
(metabolism, pathology)
- Vincristine
(pharmacology)
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