Abstract | STUDY OBJECTIVES: Determine whether treatment of sleep disorders identified in brain injured adults would result in resolution of those sleep disorders and improvement of symptoms and daytime function. METHODS: SETTING: Three academic medical centers. PARTICIPANTS: MEASUREMENTS AND RESULTS: Abnormal sleep studies were found in 22 subjects (39%), of whom 13 (23%) had OSA, 2 (3%) had PTH, 3 (5%) had narcolepsy, 4 (7%) had PLMS, and 12 had objective excessive daytime sleepiness with MSLT score < 10 minutes. Apneas, hypopneas, and snoring were eliminated by CPAP in OSA subjects, but there was no significant change in MSLT scores. Periodic limb movements were eliminated with pramipexole. One of 3 narcolepsy subjects and 1 of 2 PTH subjects had resolution of hypersomnia with modafinil. There was no significant change in FOSQ, POMS, or PVT results after treatment. CONCLUSIONS: Treatment of sleep disorders after TBI may result in polysomnographic resolution without change in sleepiness or neuropsychological function.
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Authors | Richard J Castriotta, Strahil Atanasov, Mark C Wilde, Brent E Masel, Jenny M Lai, Samuel T Kuna |
Journal | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
(J Clin Sleep Med)
Vol. 5
Issue 2
Pg. 137-44
(Apr 15 2009)
ISSN: 1550-9389 [Print] United States |
PMID | 19968047
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzhydryl Compounds
- Benzothiazoles
- Central Nervous System Stimulants
- Dopamine Agonists
- Pramipexole
- Modafinil
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Topics |
- Adult
- Benzhydryl Compounds
(therapeutic use)
- Benzothiazoles
(therapeutic use)
- Brain Injuries
(complications, rehabilitation)
- Central Nervous System Stimulants
(therapeutic use)
- Disorders of Excessive Somnolence
(drug therapy, etiology)
- Dopamine Agonists
(therapeutic use)
- Female
- Humans
- Male
- Modafinil
- Narcolepsy
(drug therapy, etiology)
- Nocturnal Myoclonus Syndrome
(drug therapy, etiology)
- Pramipexole
- Prospective Studies
- Quality of Life
- Sleep Apnea, Obstructive
(etiology, therapy)
- Sleep Wake Disorders
(etiology, therapy)
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