[Pathological diagnosis for individualized therapy of colorectal cancer].

Abstract

Pathological diagnosis is essential today for the individualized therapy of colorectal cancer. In the routine analysis of colorectal carcinomas the molecular-pathological detection of a KRAS mutation predicts unresponsiveness to EGFR-targeted antibody therapies. Moreover, the detection of mismatch-repair deficiency or high-degree microsatellite instability indicates unresponsiveness to 5-FU monotherapy. Colorectal carcinomas with high-grade microsatellite instability and their associated morphologic subtypes, such as the medullary carcinoma, exhibit a low risk of distant metastasis and might be considered as carcinomas with low need for adjuvant chemotherapy.

• Authors: T Kirchner, A Jung
• Journal: Der Pathologe (Pathologe) Vol. 31 Issue 1 Pg. 16-21 (Feb 2010) ISSN: 1432-1963 [Electronic] Germany
• Vernacular Title: Pathologische Diagnostik für die individualisierte Therapie des Dickdarmkarzinoms.
• PMID: 19957085 (Publication Type: Journal Article, Review)

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Antineoplastic Agents
• KRAS protein, human
• MSI1 protein, human
• Nerve Tissue Proteins
• Organoplatinum Compounds
• Proto-Oncogene Proteins
• RNA-Binding Proteins
• Panitumumab
• EGFR protein, human
• ErbB Receptors
• Proto-Oncogene Proteins p21(ras)
• ras Proteins
• Cetuximab
• Leucovorin
• Fluorouracil

Topics

• Antibodies, Monoclonal (adverse effects, therapeutic use)
• Antibodies, Monoclonal, Humanized
• Antineoplastic Agents (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Cetuximab
• Chemotherapy, Adjuvant
• Colorectal Neoplasms (drug therapy, genetics, pathology)
• Combined Modality Therapy
• DNA Mismatch Repair (genetics)
• DNA Mutational Analysis
• Drug Resistance, Neoplasm (genetics)
• ErbB Receptors (antagonists & inhibitors, genetics)
• Fluorouracil (adverse effects, therapeutic use)
• Gene Expression Profiling
• Gene Expression Regulation, Neoplastic (drug effects, genetics)
• Humans
• Leucovorin (adverse effects, therapeutic use)
• Microsatellite Instability
• Nerve Tissue Proteins (genetics)
• Organoplatinum Compounds (adverse effects, therapeutic use)
• Panitumumab
• Pharmacogenetics
• Practice Guidelines as Topic
• Prognosis
• Proto-Oncogene Proteins (genetics)
• Proto-Oncogene Proteins p21(ras)
• RNA-Binding Proteins (genetics)
• ras Proteins (genetics)