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Transient neonatal myasthenia gravis in a baby born to a mother with new-onset anti-MuSK-mediated myasthenia gravis.

Abstract
We describe a 30-year-old pregnant woman with undiagnosed weakness who delivered a severely weak neonate. Subsequent workup of the mother revealed myasthenia gravis with muscle-specific kinase antibodies. The infant responded to intravenous immunoglobulin and symptoms normalized. He was presumed to have an anti-muscle-specific kinase-mediated transient neonatal myasthenia gravis.
AuthorsPeter O'carroll, Tulio E Bertorini, Glady Jacob, Christopher W Mitchell, Justin Graff
JournalJournal of clinical neuromuscular disease (J Clin Neuromuscul Dis) Vol. 11 Issue 2 Pg. 69-71 (Dec 2009) ISSN: 1537-1611 [Electronic] United States
PMID19955986 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Autoantibodies
  • Autoantigens
  • Immunoglobulins, Intravenous
  • Receptors, Cholinergic
  • MUSK protein, human
  • Receptor Protein-Tyrosine Kinases
Topics
  • Adult
  • Autoantibodies (blood, immunology)
  • Autoantigens (immunology)
  • Female
  • Humans
  • Immunoglobulins, Intravenous (therapeutic use)
  • Infant, Newborn
  • Male
  • Myasthenia Gravis (immunology, physiopathology, therapy)
  • Myasthenia Gravis, Neonatal (blood, drug therapy, immunology)
  • Plasmapheresis
  • Pregnancy
  • Pregnancy Complications (immunology)
  • Receptor Protein-Tyrosine Kinases (immunology)
  • Receptors, Cholinergic (immunology)

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