Abstract | BACKGROUND: The aims of this preliminary study were to determine the alteration of serum ischemia-modified albumin (IMA) levels and to investigate whether IMA may be used as an indicator of the cardioprotective efficacy of N-acetylcysteine (NAC) in patients undergoing coronary bypass grafting (CABG). PATIENTS AND METHODS: Forty-four patients were randomized into one of two groups on the basis of cardioplegic strategies, either cold-blood cardioplegia enriched with NAC (50 mg/kg) or cold-blood cardioplegia alone. Serum IMA, cardiac troponin T (cTnT) and malondialdehyde (MDA) levels determined in NAC-enriched patients before and after CABG were compared with those of the NAC-free group. The albumin cobalt binding assay was used for IMA determination. RESULTS: Serum IMA levels were significantly elevated after cross-clamping and peaked at 6 h after reperfusion in the two groups. In NAC-enriched patients, IMA levels determined 6, 12, 24 and 48 h after reperfusion were significantly lower than those of the NAC-free group (p < or = 0.001, p < 0.001, p < 0.001 and p < 0.001, respectively). IMA returned to baseline 24 h after reperfusion differently from cTnT and MDA in the NAC-enriched group. CONCLUSIONS:
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Authors | S Caner Karahan, Ismail Koramaz, Gokalp Altun, Utku Uçar, Murat Topbaş, Ahmet Menteşe, Muge Kopuz |
Journal | European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes
(Eur Surg Res)
Vol. 44
Issue 1
Pg. 30-6
( 2010)
ISSN: 1421-9921 [Electronic] Switzerland |
PMID | 19955769
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | Copyright 2009 S. Karger AG, Basel. |
Chemical References |
- Albumins
- Cardiotonic Agents
- Troponin T
- Malondialdehyde
- Acetylcysteine
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Topics |
- Acetylcysteine
(therapeutic use)
- Albumins
(metabolism)
- Cardiotonic Agents
(therapeutic use)
- Cold Temperature
- Coronary Artery Bypass
(adverse effects)
- Female
- Heart Arrest, Induced
(adverse effects)
- Humans
- Male
- Malondialdehyde
- Middle Aged
- Myocardial Reperfusion Injury
(blood, etiology, prevention & control)
- Troponin T
(blood)
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