Juzentaihoto (TJ-48), a traditional Japanese herbal medicine, influences hemoglobin recovery during preoperative autologous blood donation and after hip surgery.

Abstract

OBJECTIVE:

Preoperative autologous blood donation is a widely used alternative to allogenic transfusion in hip surgery. However, it has been reported that autologous blood donation may induce preoperative anemia. Juzentaihoto (TJ-48) (Tsumura Co., Tokyo, Japan) is a Japanese herbal medicine that has been used to alleviate anemia. We investigated the effect of TJ-48 on anemia in the perioperative period.

PATIENTS AND METHODS:

18 hips of 18 female patients who underwent total hip arthroplasty or rotational acetabular osteotomy (RAO) were divided into two groups. Group A consisted of 9 hips of 9 patients who were treated with TJ-48 at a dose of 7.5 g per day from 21 days before surgery to the day before surgery. Group B consisted of 9 hips of 9 patients who did not take TJ-48. Preoperative autologous blood donation was performed 21, 14 and 7 days before surgery. All patients deposited 400 ml each time for a total of 1,200 ml. Hemoglobin level was recorded on preoperative Days 21, 14 and 7 and postoperative Days 1, 4, 7 and 14.

RESULTS:

During the preoperative period, repeated measures ANOVA showed a significant difference between the two groups in hemoglobin level (p = 0.04). Despite the lack of TJ-48 after surgery, the rate of hemoglobin decline in Group A was less than in Group B at all examination times. No patients with TJ-48 experienced side effects, including gastrointestinal symptoms and unusual laboratory data.

CONCLUSION:

TJ-48 is useful for treating anemia during preoperative autologous donation.

• Authors: Y Kishida, T Nishii, T Inoue, S Nishida, J Arimitsu, H Yoshikawa, N Sugano
• Journal: International journal of clinical pharmacology and therapeutics (Int J Clin Pharmacol Ther) Vol. 47 Issue 12 Pg. 716-21 (Dec 2009) ISSN: 0946-1965 [Print] Germany
• PMID: 19954709 (Publication Type: Controlled Clinical Trial, Journal Article)

Chemical References

• Drugs, Chinese Herbal
• Hemoglobins
• juzentaihoto

Topics

• Acetabulum (surgery)
• Anemia (chemically induced, prevention & control)
• Arthroplasty, Replacement, Hip
• Asian People
• Blood Transfusion, Autologous (adverse effects)
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Hemoglobins (metabolism)
• Humans
• Middle Aged
• Osteotomy
• Postoperative Complications (prevention & control)
• Preoperative Care (methods)
• Treatment Outcome