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[The clinical efficacy and safety of intravenous levofloxacin in the treatment of 4888 patients with bacterial infections: a multi-center trial].

AbstractOBJECTIVE:
To evaluate the clinical efficiency and safety of intravenous levofloxacin in the treatment of bacterial infections at a dose of 500 mg once a day.
METHODS:
Randomized, prospective, multicenter, open-label study.
RESULTS:
The total effective rate of levofloxacin was 90.8% (4103/4521). The effective rates of levofloxacin in the treatment of bacterial infections of respiratory tract, urinary tract, digestive tract and gynecologic infections and infections complicated with hematological disease were 90.2% (2884/3198), 92.3% (810/878), 91.9% (203/221), 94.5% (120/127), 88.7% (86/97), respectively. The bacterial eradication rate was 80.3% (677/843). The most common adverse drug reactions were gastrointestinal disorders (3.9%, 193/4888) and local irritation (1.7%, 84/4888), which were mild and disappeared after stopping administration.
CONCLUSION:
Intravenous levofloxacin with a dose of 500 mg once a day is effective and safe in treating bacterial infections with low adverse reactions.
AuthorsCooperation Group for Phase IV Clinical Study of Levofloxacin
JournalZhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 48 Issue 6 Pg. 492-6 (Jun 2009) ISSN: 0578-1426 [Print] China
PMID19954047 (Publication Type: Clinical Trial, Phase IV, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Anti-Bacterial Agents
  • Levofloxacin
  • Ofloxacin
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents (therapeutic use)
  • Bacterial Infections (drug therapy)
  • Female
  • Humans
  • Levofloxacin
  • Male
  • Middle Aged
  • Ofloxacin (therapeutic use)
  • Prospective Studies
  • Young Adult

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