[The study of killer cell immunoglobulin-like receptor 3DL2 gene polymorphisms and pre-eclampsia].

Abstract

OBJECTIVE:

To analyze a presumed association of gene polymorphism of killer cell immunoglobulin-like receptor three domains, long cytoplasmic tail, 2(KIR3DL2) gene with pre-eclampsia.

METHODS:

The KIR3DL2 gene A52G in exon 3 and C32T in exon 9 polymorphism were determined by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) in 95 pre-eclampsia and 91 normal pregnant women.

RESULTS:

There was significant difference between two group in exon 3 in terms of genotypes and allele (P < 0.05). There was a significant difference between two groups regarding the frequencies of exon 9 CC, CT and TT genotypes (P < 0.05). But no significant difference was found between mild pre-eclampsia and severe pre-eclampsia groups in terms of the two SNP loci (P > 0.05).

CONCLUSION:

The A52G polymorphism in exon 3 and the frequencies of C32T in exon 9 of KIR3DL2 gene polymorphism are associated with the pathogenesis of pre-eclampsia, But it has no correlation with the severity of preeclampsia.

• Authors: Xiao-lan Wang, Wei-yuan Zhang, Qi Wang, Cheng-juan Sun
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 89 Issue 21 Pg. 1468-71 (Jun 02 2009) ISSN: 0376-2491 [Print] China
• PMID: 19953898 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, KIR3DL2

Topics

• Alleles
• Exons
• Female
• Gene Frequency
• Genotype
• Humans
• Polymorphism, Restriction Fragment Length
• Pre-Eclampsia (genetics)
• Pregnancy
• Receptors, KIR3DL2 (genetics)