Pilot study of intravitreal injection of diclofenac for treatment of macular edema of various etiologies.

Abstract

PURPOSE:

The purpose of this study was to evaluate the effect of a single dose of intravitreal diclofenac, a potent nonsteroidal antiinflammatory drug, on visual acuity and central macular thickness in patients with macular edema of various etiologies.

METHODS:

In this prospective noncomparative case series, 10 eyes of 10 patients with clinically significant diabetic macular edema (n = 5), neovascular age-related macular degeneration (n = 2), pseudophakic cystoid macular edema (n = 1), macular edema secondary to old branch retinal vein occlusion (n = 1), and cystoid macular edema secondary to chronic intermediate uveitis (n = 1) received 500 microg/0.1 mL of intravitreal diclofenac. The primary outcome measure was change in visual acuity.

RESULTS:

After 2 weeks, visual acuity improved in 3 (30%) eyes (P = 0.78), did not change in 3 (30%) eyes, and decreased in 3 (30%) eyes. After 4 weeks, improvement of best-corrected visual acuity occurred in 5 (50%) eyes (P = 0.07), but in 3 eyes (30%), best-corrected visual acuity did not change, and in 1 eye (10%), visual acuity decreased. After 8 weeks, visual acuity improved in 7 (70%) eyes (P = 0.019), got worse in 1 eye (10%), and did not change in 2 eyes (20%). Central macular thickness did not decrease significantly at 8 weeks. On the basis of electroretinography, no significant changes in the amplitude of a-wave or b-wave in relation to baseline were noticed in any eye.

CONCLUSION:

Up to 8 weeks, intravitreal diclofenac treatment of eyes with macular edema of various etiologies yielded prominent improvement in visual acuity but was not associated with a significant decrease in central macular thickness. No toxic effect of intravitreal diclofenac was observed.

• Authors: Masoud Soheilian, Saeed Karimi, Alireza Ramezani, Gholam A Peyman
• Journal: Retina (Philadelphia, Pa.) (Retina) Vol. 30 Issue 3 Pg. 509-15 (Mar 2010) ISSN: 1539-2864 [Electronic] United States
• PMID: 19952986 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Diclofenac

Topics

• Aged
• Aged, 80 and over
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, adverse effects)
• Diclofenac (administration & dosage, adverse effects)
• Electroretinography
• Female
• Fluorescein Angiography
• Humans
• Injections
• Macular Edema (drug therapy, etiology, physiopathology)
• Male
• Middle Aged
• Pilot Projects
• Prospective Studies
• Retina (physiology)
• Visual Acuity (physiology)
• Vitreous Body