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Inhibition of human gastric carcinoma cell growth in vitro and in vivo by cladosporol isolated from the paclitaxel-producing strain Alternaria alternata var. monosporus.

Abstract
Cladosporol was isolated from the fermentation broth of Alternaria alternata var. monosporus obtained from the inner bark of the yew tree and mutated for many generations. We investigated the antitumor effects of cladosporol in vitro and in vivo. The growth-inhibitory effects of cladosporol in vitro against six human cancer cell lines were examined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The results showed that cladosporol selectively killed cancer cells and had a significant inhibitory effect on the human gastric carcinoma cell line MGC-803 in a concentration- and time-dependent manner. In vivo, cladosporol also showed antitumor activity in nude mice bearing MGC-803 gastric cancer xenografts. These findings suggest that cladosporol has potentially useful growth inhibitory effects on human gastric carcinoma cell lines.
AuthorsJiepeng Chen, Xuelian Qiu, Ronghua Wang, Lili Duan, Shouxian Chen, Jianguang Luo, Lingyi Kong
JournalBiological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 32 Issue 12 Pg. 2072-4 (Dec 2009) ISSN: 1347-5215 [Electronic] Japan
PMID19952432 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Naphthalenes
  • cladosporol
  • Paclitaxel
Topics
  • Alternaria (chemistry)
  • Animals
  • Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology, therapeutic use)
  • Carcinoma (drug therapy)
  • Cell Death (drug effects)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Naphthalenes (isolation & purification, pharmacology, therapeutic use)
  • Neoplasms (drug therapy)
  • Paclitaxel
  • Plant Bark
  • Stomach Neoplasms (drug therapy)
  • Taxus
  • Transplantation, Heterologous

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