Abstract | BACKGROUND: METHODS: Sixteen Sprague-Dawley rats were used as study group and 9 as control. In the study group, a plastic extender with a trumpet-shaped distal end was inserted into the lower esophagus to dilate the cardia, the pylorus was ligated. One ml of 0.1 mol/L hydrochloric acid was injected into the stomach. While a simple laparotomy was performed for control animals. All animals from two groups were sacrificed 24 hours after operation. Then tracheotomy was carried and the bronchoalveolar lavage fluid was collected in all animals. Cells in the fluid were counted and levels of interleukin (IL)-5, -6, -8 in it were measured. RESULTS: Compared with control group, the study group presented a neutrophil pattern of airway inflammation and an elevated concentration of IL-5, -6, -8 with no significant difference regarding eosinophil count. CONCLUSION:
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Authors | Yun-gang Lai, Zhong-gao Wang, Feng Ji, Ji-min Wu, Xiu Chen, Zhen Li, Shu-kui Dong |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 122
Issue 22
Pg. 2775-8
(Nov 20 2009)
ISSN: 2542-5641 [Electronic] China |
PMID | 19951613
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Interleukin-5
- Interleukin-6
- Interleukin-8
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Topics |
- Animals
- Asthma
(etiology)
- Bronchoalveolar Lavage Fluid
(immunology)
- Disease Models, Animal
- Female
- Gastroesophageal Reflux
(complications)
- Inflammation
(etiology)
- Interleukin-5
(analysis)
- Interleukin-6
(analysis)
- Interleukin-8
(analysis)
- Male
- Rats
- Rats, Sprague-Dawley
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