Abstract |
The production of the monocyte chemoattractant MCP-1 suggests a common mechanism for the recruitment of monocytes/macrophages and provides an explanation for monocyte/macrophage infiltration frequently observed in solid tumors. The regulated production of MCP-1 by non-transformed cells further substantiates the suggestion that MCP-1 is an important inflammatory mediator and is involved in the recruitment of monocytes in a number of pathologic or physiologic conditions.
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Authors | D T Graves, A J Valente |
Journal | Biochemical pharmacology
(Biochem Pharmacol)
Vol. 41
Issue 3
Pg. 333-7
(Feb 01 1991)
ISSN: 0006-2952 [Print] England |
PMID | 1994892
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
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Chemical References |
- Chemokine CCL2
- Chemotactic Factors
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Topics |
- Animals
- Chemokine CCL2
- Chemotactic Factors
(physiology)
- Humans
- Macrophages
(physiology)
- Monocytes
(physiology)
- Neoplasms
(physiopathology)
- Tumor Cells, Cultured
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