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Monocyte chemotactic proteins from human tumor cells.

Abstract
The production of the monocyte chemoattractant MCP-1 suggests a common mechanism for the recruitment of monocytes/macrophages and provides an explanation for monocyte/macrophage infiltration frequently observed in solid tumors. The regulated production of MCP-1 by non-transformed cells further substantiates the suggestion that MCP-1 is an important inflammatory mediator and is involved in the recruitment of monocytes in a number of pathologic or physiologic conditions.
AuthorsD T Graves, A J Valente
JournalBiochemical pharmacology (Biochem Pharmacol) Vol. 41 Issue 3 Pg. 333-7 (Feb 01 1991) ISSN: 0006-2952 [Print] England
PMID1994892 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
Chemical References
  • Chemokine CCL2
  • Chemotactic Factors
Topics
  • Animals
  • Chemokine CCL2
  • Chemotactic Factors (physiology)
  • Humans
  • Macrophages (physiology)
  • Monocytes (physiology)
  • Neoplasms (physiopathology)
  • Tumor Cells, Cultured

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