Currently approved prophylactic HPV vaccines.

Abstract

Cervarix and Gardasil are two prophylactic HPV vaccines designed primarily for cervical cancer prevention. Cervarix is effective against HPV-16, -18, -31, -33 and -45, the five most common cancer-causing types, including most causes of adenocarcinoma for which we cannot screen adequately. Gardasil is effective against HPV-16, 18 and 31, three common squamous cell cancer-causing types. In addition, Gardasil is effective against HPV-6 and -11, causes of genital warts and respiratory papillomatosis. The most important determinant of vaccine impact to reduce cervical cancer is its duration of efficacy. To date, Cervarix's efficacy is proven for 6.4 years and Gardasil's for 5 years.

• Authors: Diane M Harper
• Journal: Expert review of vaccines (Expert Rev Vaccines) Vol. 8 Issue 12 Pg. 1663-79 (Dec 2009) ISSN: 1744-8395 [Electronic] England
• PMID: 19943762 (Publication Type: Journal Article, Review)

Chemical References

• Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
• Papillomavirus Vaccines
• human papillomavirus vaccine, L1 type 16, 18

Topics

• Adenocarcinoma (prevention & control, virology)
• Adolescent
• Adult
• Alphapapillomavirus (immunology)
• Clinical Trials as Topic
• Condylomata Acuminata (prevention & control, virology)
• Drug Approval
• Female
• Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
• Humans
• Papillomavirus Infections (prevention & control, virology)
• Papillomavirus Vaccines (administration & dosage, adverse effects, immunology)
• Treatment Outcome
• Uterine Cervical Neoplasms (prevention & control, virology)
• Young Adult
• Uterine Cervical Dysplasia (prevention & control, virology)