[Experience in using normofundin and sterofundin solutions for the correction of hypernatremia].

Abstract

The efficacy of Sterofundin, Normofundin, and physiological solutions in correcting hypernatremia and impaired acid-base balance was analyzed in patients with sellar region tumors. Twenty-one patients were enrolled in the study; three groups were formed. Physiological solution added by 4% of potassium chloride and 25% magnesium sulfate solution was used in Group 1 (n = 7). Normofundin was employed in Group 2 (n = 7). Sterofundin was applied to Group 3 (n = 7). The volume of administered fluid corresponded to the sum of volumes of basic needs and those of fluid losses. The study revealed that the most adequate correction of hypernatremia was seen with the use of Sterofundin. The use of Normofundin is associated with a risk of a rapid and significant reduction in the level of sodium and that of physiological solution fails to correct hypernatremia. Metabolic alkalosis was typical for all the patients included into the study. Its effective correction was noted only when Sterofundin was used.

• Authors: K A Popugaev, I A Savin, N V Kurdiumova, V I Luk'ianov
• Journal: Anesteziologiia i reanimatologiia (Anesteziol Reanimatol) 2009 Sep-Oct Issue 5 Pg. 39-41 ISSN: 0201-7563 [Print] Russia (Federation)
• PMID: 19938715 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Crystalloid Solutions
• Isotonic Solutions
• Rehydration Solutions
• Sodium

Topics

• Craniopharyngioma (metabolism, surgery)
• Crystalloid Solutions
• Humans
• Hypernatremia (etiology, prevention & control)
• Isotonic Solutions (administration & dosage, therapeutic use)
• Pituitary Neoplasms (metabolism, surgery)
• Rehydration Solutions (administration & dosage, therapeutic use)
• Sodium (blood)
• Treatment Outcome