Urinary pregnanetriol excretion in hirsutism.

Abstract

Eighteen consecutive hirsute women attending an endocrine clinic have been studied by measurement of the urinary pregnanetriol excretion before and following the concurrent administration of corticotrophin and metyrapone. An abnormal increment in pregnanetriol excretion was observed in 11 of these 18 patients. It is suggested that this is evidence that an adrenal abnormality, probably operative at the 21-hydroxylase level, might be a factor responsible for the hirsutism in these 11 patients. Five adrenalectomized women who were also studied showed no significant increase in urinary pregnanetriol excretion in response to concurrent corticotrophin and metyrapone administration.

• Authors: W Van't Hoff, E J Bicknell, P M Horrocks, J A Fleetwood, M Inthuprapa, R Hall
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 80 Issue 2 Pg. 373-9 (Oct 15 1977) ISSN: 0009-8981 [Print] Netherlands
• PMID: 199379 (Publication Type: Journal Article)

Chemical References

• Pregnanetriol
• Adrenocorticotropic Hormone
• Metyrapone

Topics

• Adrenalectomy
• Adrenocorticotropic Hormone
• Adult
• Female
• Hirsutism (urine)
• Humans
• Metyrapone
• Middle Aged
• Pregnanetriol (urine)
• Time Factors