Secondary tics or tourettism associated with a brain tumor.

Abstract

Tourette syndrome is generally considered to be a genetic disorder, but symptoms mimicking Tourette syndrome can be secondary to an underlying lesion disrupting the basal ganglia circuitry. Described here is a case of secondary tics, or tourettism, in a child with a large oligodendroglioma of the right temporal lobe extending to the basal ganglia. He presented with attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and stimulant-induced tic disorder at the age of 11 years, and later also had also seizures. The family history was unremarkable. Cranial magnetic resonance imaging disclosed a right temporal lobe tumor extending to the basal ganglia. An alpha-[(11)C]methyl-l-tryptophan positron emission tomography scan showed asymmetric uptake in the basal ganglia and intense uptake in the tumor. He had a lesionectomy, and the histopathologic diagnosis was oligodendroglioma. Neuropsychologic testing after surgery revealed no attention-deficit hyperactivity disorder symptomatology, and only minimal features of obsessive-compulsive disorder. The present case provides additional evidence supporting the role of basal ganglia circuitry in the pathophysiology of tic disorder and its comorbid states. Children who present with attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and tic disorder of late onset in the absence of family history should be further investigated with neuroimaging to exclude the presence of a secondary cause.

• Authors: Aimee F Luat, Michael E Behen, Csaba Juhász, Sandeep Sood, Harry T Chugani
• Journal: Pediatric neurology (Pediatr Neurol) Vol. 41 Issue 6 Pg. 457-60 (Dec 2009) ISSN: 1873-5150 [Electronic] United States
• PMID: 19931171 (Publication Type: Case Reports, Journal Article)

Topics

• Attention Deficit Disorder with Hyperactivity (etiology, pathology, surgery)
• Basal Ganglia (metabolism, pathology, surgery)
• Brain Neoplasms (complications, pathology, surgery)
• Child
• Humans
• Magnetic Resonance Imaging
• Male
• Neoplasm Recurrence, Local (radiotherapy)
• Neuropsychological Tests
• Obsessive-Compulsive Disorder (etiology, pathology, surgery)
• Oligodendroglioma (complications, pathology, surgery)
• Positron-Emission Tomography
• Tics (etiology, pathology, surgery)
• Tourette Syndrome (etiology, pathology, surgery)
• Treatment Outcome