Abstract | BACKGROUND AND AIMS: METHODS: RESULTS: All patients tolerated the operations well with no significant complications. The platelet count was significantly higher in the laparoscopic splenectomy group than in the partial splenic embolization group at 1 and 2 weeks after the intervention. Interferon therapy was stopped in two patients in the partial splenic embolization group due to recurrent thrombocytopenia whereas all patients in the laparoscopic splenectomy group completed interferon therapy. The planned anticancer therapies were performed in all patients, and were completed in all patients without any problems or major complications. CONCLUSION: Laparoscopic splenectomy may be superior to partial splenic embolization as a supportive intervention for cirrhotic patients with hypersplenism. Future prospective, randomized controlled patient studies are required to confirm these findings.
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Authors | Morimasa Tomikawa, Tomohiko Akahoshi, Keishi Sugimachi, Yasuharu Ikeda, Kisaku Yoshida, Yuichi Tanabe, Hirofumi Kawanaka, Kenji Takenaka, Makoto Hashizume, Yoshihiko Maehara |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 25
Issue 2
Pg. 397-402
(Feb 2010)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 19929930
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Interferons
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Topics |
- Aged
- Antineoplastic Agents
(therapeutic use)
- Carcinoma, Hepatocellular
(complications, therapy)
- Catheter Ablation
- Embolization, Therapeutic
(adverse effects)
- Female
- Hepatectomy
- Humans
- Hypersplenism
(etiology, surgery, therapy)
- Interferons
(therapeutic use)
- Japan
- Laparoscopy
(adverse effects)
- Leukopenia
(etiology, prevention & control)
- Liver Cirrhosis
(complications, therapy)
- Liver Neoplasms
(complications, therapy)
- Male
- Middle Aged
- Platelet Count
- Splenectomy
(adverse effects, methods)
- Thrombocytopenia
(etiology, prevention & control)
- Time Factors
- Treatment Outcome
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