Abstract | CONTEXT: OBJECTIVE: The objective of the study was to investigate the relationship between FGF-21, GH, and IGF-I in AN. DESIGN: This was a cross-sectional study. SETTING: The study was conducted at a clinical research center. PATIENTS: Patients included 23 girls: 11 with AN (16.5 +/- 0.6 yr) and 12 normal-weight controls (15.7 +/- 0.5 yr). INTERVENTIONS: There were no interventions. MAIN OUTCOME MEASURES: RESULTS:
FGF-21 levels were significantly higher in AN compared with controls, and there was a positive correlation between FGF-21 and GH-AUC (P = 0.03) after controlling for percent body fat and insulin resistance. In subjects with elevated FGF-21 levels, there was a strong inverse association between FGF-21 and IGF-I (R = -0.88, P = 0.004). FGF-21 strongly correlated with total area under the curve for leptin (R = 0.67, P = 0.02). CONCLUSIONS:
FGF-21 levels are higher in AN independent of the effects of percent body fat and insulin resistance. The positive association between FGF-21 and GH-AUC and the inverse association between elevated FGF-21 levels and IGF-I suggests that above the normal range, FGF-21 may mediate a state of GH resistance in AN.
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Authors | Pouneh K Fazeli, Madhusmita Misra, Mark Goldstein, Karen K Miller, Anne Klibanski |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 95
Issue 1
Pg. 369-74
(Jan 2010)
ISSN: 1945-7197 [Electronic] United States |
PMID | 19926712
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Blood Glucose
- Insulin
- Leptin
- fibroblast growth factor 21
- Human Growth Hormone
- Fibroblast Growth Factors
- Insulin-Like Growth Factor I
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Topics |
- Adolescent
- Anorexia Nervosa
(blood, diagnosis, metabolism)
- Area Under Curve
- Blood Glucose
(analysis)
- Body Composition
(physiology)
- Case-Control Studies
- Drug Resistance
(physiology)
- Female
- Fibroblast Growth Factors
(blood, physiology)
- Health
- Human Growth Hormone
(blood, physiology)
- Humans
- Insulin
(blood)
- Insulin-Like Growth Factor I
(analysis)
- Leptin
(blood)
- Prognosis
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