Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia cells.

Abstract

Six dammarane-type saponins, including three new compounds, floralginsenosides Ta-Tc (1-3), and three known, floralginsenoside Td (4), ginsenoside F(1) (5), and ginsenoside F(5) (6), were isolated from the flower buds of Panax ginseng. Floralginsenoside Td (4) was first isolated from natural plant sources. Their structures were elucidated on the basis of extensive chemical and spectroscopic methods. Compounds 1, 5, and 6 showed cytotoxic activities towards the HL-60 human leukemia cell line with respective IC(50) values of 36.3, 23.2, and 62.4microM. In addition, after the HL-60 cells were treated with these compounds, several apoptosis events, including chromatin condensation and increase in the population of sub-G1 hypodiploid cells, were observed.

• Authors: Huu Tung Nguyen, Gyu Yong Song, Jeong-Ah Kim, Jae-Hee Hyun, Hee-Kyoung Kang, Young Ho Kim
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 20 Issue 1 Pg. 309-14 (Jan 01 2010) ISSN: 1464-3405 [Electronic] England
• PMID: 19926279 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2009 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents, Phytogenic
• Saponins
• Triterpenes
• dammarane

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, toxicity)
• Flowers (chemistry)
• HL-60 Cells
• Humans
• Leukemia (drug therapy)
• Magnetic Resonance Spectroscopy
• Molecular Conformation
• Panax (chemistry)
• Saponins (chemistry, isolation & purification, toxicity)
• Triterpenes (chemistry)