Abstract |
The Mi-2/NuRD chromatin remodeling complex links multiple transcriptional regulatory processes including histone deacetylation, histone demethylation, nucleosome mobilization and recruitment of other regulatory proteins. In some contexts, Mi-2/NuRD functions as a barrier to transcriptional activation by working in opposition to other chromatin remodelers such as SWI/SNF. Alternatively, the Mi-2beta ATPase subunit of Mi-2/NuRD can promote transcription. Together, these gatekeeper functions of Mi-2/NuRD influence cell fate decisions by modulating transcriptional activity. Recent studies have shown the importance of Mi-2/NuRD both in maintaining hematopoietic stem cell (HSC) pools and in normal lineage progression. Furthermore, components of Mi-2/NuRD complexes are modular co-repressors/co-activators comprising multiple protein subunits that have been linked directly to oncogenesis and have potential as therapeutic targets for cancer treatment. Mi-2/NuRD's essential functions in metazoan cell fates and activities underscore its importance as a focal point of epigenetic research.
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Authors | Julita Ramírez, James Hagman |
Journal | Epigenetics
(Epigenetics)
Vol. 4
Issue 8
Pg. 532-6
(Nov 16 2009)
ISSN: 1559-2308 [Electronic] United States |
PMID | 19923891
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Mi-2 Nucleosome Remodeling and Deacetylase Complex
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Topics |
- Cell Differentiation
- Epigenesis, Genetic
- Hematopoietic Stem Cells
(cytology)
- Mi-2 Nucleosome Remodeling and Deacetylase Complex
(genetics, metabolism)
- Models, Biological
- Neoplasms
(genetics, metabolism)
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