Abstract | BACKGROUND: OBJECTIVE: DESIGN:
alpha-TTP knockout mice were infected with Plasmodium berghei ANKA, and survival rate, parasitemia, brain histologic alterations, and brain barrier permeability were assessed. In addition, mRNA expression of the cytokines and adhesion molecules involved in this neurologic pathology were monitored. RESULTS:
alpha-TTP knockout mice infected with P. berghei ANKA did not exhibit any clinical or pathologic signs of CM, and a histologic analysis of the brain tissues in these animals showed no alteration of blood-brain barrier integrity compared with that in control mice. Interestingly, protection of the blood-brain barrier in these infected alpha-TTP knockout mice was lost when dietary supplementation with vitamin E was added to their diet. Moreover, interleukins and adhesion molecule transcripts in the brain of control mice were significantly up-regulated compared with those in the alpha-TTP knockout mice. CONCLUSION: It appears that a deficiency of alpha-tocopherol in the circulation prevents CM and suggests that alpha-TTP is a putative target for the early prevention of CM.
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Authors | Maria S Herbas, Mikiko Okazaki, Eri Terao, Xuenan Xuan, Hiroyuki Arai, Hiroshi Suzuki |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 91
Issue 1
Pg. 200-7
(Jan 2010)
ISSN: 1938-3207 [Electronic] United States |
PMID | 19923370
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carrier Proteins
- Cytokines
- RNA, Messenger
- alpha-tocopherol transfer protein
- Vitamin A
- Vitamin E
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Topics |
- Animals
- Carrier Proteins
(genetics)
- Cytokines
(genetics)
- Malaria, Cerebral
(mortality, prevention & control)
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Oxidative Stress
- Plasmodium
- Plasmodium berghei
- RNA, Messenger
(genetics)
- Vitamin A
(blood)
- Vitamin A Deficiency
(genetics)
- Vitamin E
(metabolism)
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