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Sorting out endosomes in the WASH.

Abstract
Two new studies published in this issue of Developmental Cell by Derivery et al. and Gomez and Billadeau reveal that WASH (Wiskott-Aldrich syndrome protein and SCAR homolog) activates Arp2/3 on endosomes and plays a critical role in the fission of tubules that serve as transport intermediates during endosome sorting.
AuthorsJames E Bear
JournalDevelopmental cell (Dev Cell) Vol. 17 Issue 5 Pg. 583-4 (Nov 2009) ISSN: 1878-1551 [Electronic] United States
PMID19922862 (Publication Type: Comment, Journal Article)
Chemical References
  • Actin-Related Protein 2-3 Complex
  • Wiskott-Aldrich Syndrome Protein
Topics
  • Actin-Related Protein 2-3 Complex (metabolism)
  • Animals
  • Endosomes (metabolism)
  • Humans
  • Protein Transport
  • Wiskott-Aldrich Syndrome Protein (metabolism)

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